Plasma rich in quercetin metabolites induces G2/M arrest by upregulating PPAR-γ expression in human A549 lung cancer cells.

@article{Yeh2011PlasmaRI,
  title={Plasma rich in quercetin metabolites induces G2/M arrest by upregulating PPAR-γ expression in human A549 lung cancer cells.},
  author={Shu-Lan Yeh and Chiao-Lin Yeh and Shu-Ting Chan and Cheng-Hung Chuang},
  journal={Planta medica},
  year={2011},
  volume={77 10},
  pages={992-8}
}
In this study, we incubated human A549 lung cancer cells with quercetin-metabolite-enriched plasma (QMP) obtained from Mongolian gerbils 2 h after quercetin feeding (100 mg/kg body wt/week). We investigated the effects of QMP on the growth of A549 cells and the possible mechanisms for these effects. We found that QMP but not control plasma (CP) reduced the cell growth in A549 cells. QMP led to cell cycle arrest at the G (2)/M phase by downregulating the expression of cdk1 and cyclin B. QMP but… CONTINUE READING
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