Plasma protein induction by isolated hepatocytes

  title={Plasma protein induction by isolated hepatocytes},
  author={Laura J. Crane and David Lee Miller},
  journal={Molecular and Cellular Biochemistry},
Hepatocytes can be maintained in culture for periods of a few hours to many days. This review summarizes the metabolic characteristics of these cultures and describes their use in studying the regulation of plasma protein synthesis. Hormones selectively stimulate the synthesis of certain proteins. Cortisol stimulates the synthesis of fibrinogen and other acute-phase proteins; whereas, insulin stimulates albumin synthesis. In the latter case insulin increases the rate of a nuclear process… CONTINUE READING
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