Plasma protein binding of phencyclidine.

  title={Plasma protein binding of phencyclidine.},
  author={Harlan Giles and William A. Corrigall and V. Khouw and Edward M. Sellers},
  journal={Clinical pharmacology and therapeutics},
  volume={31 1},
In healthy male subjects (n = 12) phencyclidine (PCP) free fraction was 22.0 +/- 2.8 % (mean +/- SD). In male patients with mild to moderate alcoholic liver disease (n = 16) free fraction (23.0 +/- 3.4%) was of the same order as in healthy subjects although age and the concentrations of albumin, bilirubin, and high-density lipoproteins were different (P less than 0.05). Free fraction (76.2 /+- 0.06%) in fatty acid free human serum albumin (HSA, 4.4 gm/dl) was far greater than in plasma. Both… CONTINUE READING