Plasma protein binding of amphotericin B and pharmacokinetics of bound versus unbound amphotericin B after administration of intravenous liposomal amphotericin B (AmBisome) and amphotericin B deoxycholate.

@article{Bekersky2002PlasmaPB,
  title={Plasma protein binding of amphotericin B and pharmacokinetics of bound versus unbound amphotericin B after administration of intravenous liposomal amphotericin B (AmBisome) and amphotericin B deoxycholate.},
  author={Ihor Bekersky and Robert Michael George Fielding and Dawna E Dressler and Jean Wenqing. Lee and Donald N. Buell and Thomas John Walsh},
  journal={Antimicrobial agents and chemotherapy},
  year={2002},
  volume={46 3},
  pages={
          834-40
        }
}
Unilamellar liposomal amphotericin B (AmBisome) (liposomal AMB) reduces the toxicity of this antifungal drug. The unique composition of liposomal AMB stabilizes the liposomes, producing higher sustained drug levels in plasma and reducing renal and hepatic excretion. When liposomes release their drug payload, unbound, protein-bound, and liposomal drug pools may exist simultaneously in the body. To determine the amounts of drug in these pools, we developed a procedure to measure unbound AMB in… CONTINUE READING

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