Plasma protein binding interaction of prednisone and prednisolone.

@article{Boudinot1984PlasmaPB,
  title={Plasma protein binding interaction of prednisone and prednisolone.},
  author={F. Douglas Boudinot and William J. Jusko},
  journal={Journal of steroid biochemistry},
  year={1984},
  volume={21 3},
  pages={337-9}
}
The plasma protein binding interaction of prednisone and prednisolone were characterized by equilibrium dialysis. Prednisone and prednisolone are bound equally but weakly to human albumin (affinity constant, K approximately equal to 1 X 10(3) M-1). Transcortin affinity for prednisolone is 10-fold greater (51.3 X 10(6) M-1) than that for prednisone (4.3 X 10(6) M-1). In competition under pharmacologic conditions, prednisolone inhibits prednisone binding to transcortin producing linear binding… CONTINUE READING