Plasma propafenone concentration in the evaluation of anti-arrhythmic efficacy.

  title={Plasma propafenone concentration in the evaluation of anti-arrhythmic efficacy.},
  author={G. Steurer and Heinz Stefan Weber and Herwig Schmidinger and Herbert Plass and Bernhard Frey and Helmut Puererfellner and Peter Probst},
  journal={European heart journal},
  volume={12 4},
The anti-arrhythmic drug efficacy of oral propafenone therapy (300 mg to 900 mg per day) was studied in relation to propafenone and hydroxy-propafenone plasma concentrations in 70 outpatients (46 males, 24 females, mean age 57 +/- 12 years) followed up for 24 +/- 32 months. On average 1.7 plasma concentration measurements were performed per patient. The arrhythmias were effectively controlled in 32 patients, but in another 32 patients propafenone therapy was ineffective; in six patients the… CONTINUE READING


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