Plasma phenylalanine: tyrosine ratios during high-dose methotrexate-citrovorum "rescue".

@article{Hilton1982PlasmaPT,
  title={Plasma phenylalanine: tyrosine ratios during high-dose methotrexate-citrovorum "rescue".},
  author={M. Hilton and C. C. Patel and S. Bertolone and D. Kmetz and L. Clark},
  journal={Medical and pediatric oncology},
  year={1982},
  volume={10 4},
  pages={
          389-95
        }
}
We have measured phenylalanine and tyrosine in the plasma of patients with osteogenic sarcoma undergoing chemotherapy with high-dose methotrexate (HDMTX) citrovorum factor rescue (CFR). During 14 treatments in six different patients, the phenylalanine to tyrosine ratio (PHE/TYR) at 21 to 38 hours was elevated over pretreatment levels. The observed increase in plasma phenylalanine is attributed to inhibition by MTX of the phenylalanine hydroxylase system of the liver, which is not folate… Expand

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