Plasma pharmacokinetics of the mycotoxin deoxynivalenol following oral and intravenous administration to sheep.

@article{Prelusky1985PlasmaPO,
  title={Plasma pharmacokinetics of the mycotoxin deoxynivalenol following oral and intravenous administration to sheep.},
  author={Danial Prelusky and Doug M Veira and H. L. Trenholm},
  journal={Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes},
  year={1985},
  volume={20 6},
  pages={603-24}
}
The pharmacokinetics of deoxynivalenol (DON) were studied in sheep after administrating intravenous and oral doses (0.5 and 5.0 mg/kg, respectively). The plasma concentrations were measured using an electron-capture gas chromatographic method. After iv administration DON plasma levels were found to decrease biexponentially, showing a rapid distribution phase (t 1/2 alpha = 12-23 min), followed by a slower elimination phase (t 1/2 beta = 57-78 min). Only trace levels of DON could be detected in… CONTINUE READING