Plasma pharmacokinetics of a liver-selective nitric oxide-donating diazeniumdiolate in the male C57BL/6 mouse.

@article{Stinson2002PlasmaPO,
  title={Plasma pharmacokinetics of a liver-selective nitric oxide-donating diazeniumdiolate in the male C57BL/6 mouse.},
  author={Sherman F. Stinson and Tony House and Chris Bramhall and Joseph E. Saavedra and Larry Kay Keefer and Raymond Whiting Nims},
  journal={Xenobiotica; the fate of foreign compounds in biological systems},
  year={2002},
  volume={32 4},
  pages={
          339-47
        }
}
1. The single-dose plasma pharmacokinetics of O(2)-vinyl 1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate (V-PYRRO/NO) following intravenous (i.v.) and intraperitoneal (i.p.) bolus administration to the male C57BL/6 mouse was studied in an effort to characterize the disposition of the agent and to serve as a basis for the design of in vivo efficacy studies. 2. Plasma V-PYRRO/NO concentrations declined rapidly in a bi-exponential manner after i.v. administration of 5 mg kg(-1) body weight to mouse… CONTINUE READING
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