Plasma osteopontin levels and expression in adipose tissue are increased in obesity.

@article{GmezAmbrosi2007PlasmaOL,
  title={Plasma osteopontin levels and expression in adipose tissue are increased in obesity.},
  author={Javier G{\'o}mez-Ambrosi and Victoria Catal{\'a}n and Beatriz Ram{\'i}rez and Amaia Rodr{\'i}guez and Inmaculada Colina and C. Silva and Fernando Rotellar and Carmen Mugueta and M. J. Gil and J. Alvarez Cienfuegos and Javier Salvador and Gema Fr{\"u}hbeck},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2007},
  volume={92 9},
  pages={3719-27}
}
CONTEXT Obesity acts as a cardiovascular risk factor by mechanisms that are not fully understood. Osteopontin (OPN) is a proinflammatory mediator involved in tissue remodeling that plays a role in atherosclerosis and diabetes. OBJECTIVE The aim of the present study was to compare the circulating concentrations of OPN and its mRNA expression in omental adipose tissue of lean, overweight, and obese individuals and to analyze the effect of weight loss. SUBJECTS AND METHODS Plasma… CONTINUE READING