Plasma of preeclamptic women stimulates and then inhibits endothelial prostacyclin.

@article{Baker1996PlasmaOP,
  title={Plasma of preeclamptic women stimulates and then inhibits endothelial prostacyclin.},
  author={Philip N. Baker and Sandra T Davidge and J Barankiewicz and James M Roberts},
  journal={Hypertension},
  year={1996},
  volume={27 1},
  pages={56-61}
}
We propose that the dichotomy between the in vivo reduction in intravascular prostacyclin production that occurs in preeclampsia and the in vitro stimulatory effect of plasma from preeclamptic patients on endothelial cell prostacyclin production is due to differential effects of chronic versus acute exposure to the plasma. We studied the acute versus chronic effects of 2% plasma from healthy pregnant and preeclamptic subjects by measuring endothelial prostacyclin production at different time… CONTINUE READING