Plasma of patients with chronic urticaria shows signs of thrombin generation, and its intradermal injection causes wheal-and-flare reactions much more frequently than autologous serum.

@article{Asero2006PlasmaOP,
  title={Plasma of patients with chronic urticaria shows signs of thrombin generation, and its intradermal injection causes wheal-and-flare reactions much more frequently than autologous serum.},
  author={Riccardo Asero and Alberto Tedeschi and Piersandro Riboldi and Massimo Cugno},
  journal={The Journal of allergy and clinical immunology},
  year={2006},
  volume={117 5},
  pages={1113-7}
}
BACKGROUND Several aspects of the pathogenesis of chronic urticaria (CU) remain contradictory. Autologous serum skin tests (ASSTs) and in vitro histamine release assays seem to look into distinct aspects of the disease, and the specificity of ASST has been questioned. OBJECTIVE We compared the autologous plasma skin test (APST) with ASST to detect autoreactivity in patients with CU. The clotting process was investigated as well by measuring in vivo thrombin generation. METHODS A total of 96… CONTINUE READING
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