Plasma obestatin is lower at fasting and not suppressed by insulin in insulin-resistant humans.

@article{AnderwaldStadler2007PlasmaOI,
  title={Plasma obestatin is lower at fasting and not suppressed by insulin in insulin-resistant humans.},
  author={Marietta Anderwald-Stadler and Michel Krebs and Miriam Promintzer and Martina Mandl and Martin Georg Bischof and Peter Nowotny and Thomas Kaestenbauer and Anton Luger and Rudolf Prager and Christian Heinz Anderwald},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2007},
  volume={293 5},
  pages={E1393-8}
}
Obestatin, a recently discovered 23-amino acid peptide, is involved in the regulation of appetite and body weight in antagonistic fashion to ghrelin, both deriving from a common precursor peptide. Ghrelin was shown to be associated with insulin resistance, which may also affect obestatin. We investigated the association between insulin resistance and plasma concentrations of obestatin and ghrelin in nondiabetic individuals with high (IS; n = 18, 13 females and 5 males, age 47 +/- 2 yr, BMI = 25… CONTINUE READING