Plasma norepinephrine response to a cold pressor test in subtypes of depressive illness.

Abstract

Noradrenergic systems have been shown to be disordered in depressive illness. The plasma norepinephrine response to a cold pressor test was used to investigate norepinephrine activity in subtypes of depressive illness. Patients with melancholic or psychotic depression, non-melancholic depression, general anxiety disorder and normal control subjects had a cold pressor test carried out under standard conditions. Blood samples were taken to measure plasma norepinephrine during the test. The plasma norepinephrine response to a cold pressor test was reduced in the melancholic/psychotic depressed patients compared to control subjects. No other intergroup comparisons were statistically significant. These results suggest noradrenergic systems are disturbed and subresponsive to stress in melancholic/psychotic depressed patients. This does not appear related to other clinical or biochemical factors.

Cite this paper

@article{Kelly1998PlasmaNR, title={Plasma norepinephrine response to a cold pressor test in subtypes of depressive illness.}, author={Christopher B. Kelly and Sarah E J Cooper}, journal={Psychiatry research}, year={1998}, volume={81 1}, pages={39-50} }