Plasma nitroso compounds are decreased in patients with endothelial dysfunction.

@article{Heiss2006PlasmaNC,
  title={Plasma nitroso compounds are decreased in patients with endothelial dysfunction.},
  author={Christian Heiss and T. H. Lauer and Andr{\'e} Dejam and Petra Kleinbongard and Sandra Hamada and Tienush Rassaf and Simone Matern and Martin Feelisch and Malte Kelm},
  journal={Journal of the American College of Cardiology},
  year={2006},
  volume={47 3},
  pages={573-9}
}
OBJECTIVES We investigated whether plasma nitros(yl)ated species (RXNOs) that mediate systemic nitric oxide (NO) bioactivity are depleted in individuals with cardiovascular risk factors and endothelial dysfunction. BACKGROUND Endothelium-derived NO acts not only as a regional messenger but exerts significant systemic effects via formation of circulating RXNOs delivering NO to sites of impaired production. METHODS Endothelial function was assessed in 68 patients with one to four major… CONTINUE READING

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