Plasma nicotine and cotinine levels following intravenous nicotine self-administration in rats

@article{Shoaib1999PlasmaNA,
  title={Plasma nicotine and cotinine levels following intravenous nicotine self-administration in rats},
  author={Mohammed Shoaib and Ian P. Stolerman},
  journal={Psychopharmacology},
  year={1999},
  volume={143},
  pages={318-321}
}
  Rationale: The route of nicotine administration between animal models and humans is very different and further investigation by determining levels of nicotine entering into the circulatory system is warranted. Objective: The present study addresses the validity of the rat self-administration procedure by comparing plasma levels of nicotine in the rat with levels reported in smokers following cigarette consumption. Methods: Plasma levels of nicotine and its metabolite cotinine were measured in… CONTINUE READING
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