Plasma naltrexone during opioid detoxification.

  title={Plasma naltrexone during opioid detoxification.},
  author={Timothy B McDonald and Rosalind Berkowitz and William E. Hoffman},
  journal={Journal of addictive diseases},
  volume={19 4},
Orogastric naltrexone is used for opioid detoxification, but it is not known how gastric absorption affects plasma concentrations of the drug. We measured plasma naltrexone during orogastric naltrexone, given in repeated doses of 12.5 mg, 25 mg, 50 mg and 50 mg. Plasma naltrexone was measured after each naltrexone dose. The increase in plasma naltrexone was highly variable between patients during orogastric administration. Adequate detoxification was questioned in 4 of 10 patients because… CONTINUE READING

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