Plasma n-3 fatty acids and clinical outcomes in recent-onset rheumatoid arthritis

@article{Proudman2015PlasmaNF,
  title={Plasma n-3 fatty acids and clinical outcomes in recent-onset rheumatoid arthritis},
  author={Susanna M Proudman and Leslie G. Cleland and Robert Metcalf and Thomas R Sullivan and Llewellyn D J Spargo and Michael James},
  journal={British Journal of Nutrition},
  year={2015},
  volume={114},
  pages={885 - 890}
}
Abstract A randomised controlled trial (RCT) of high-dose v. low-dose fish oil in recent-onset rheumatoid arthritis (RA) demonstrated that the group allocated to high-dose fish oil had increased remission and decreased failure of disease-modifying anti-rheumatic drug (DMARD) therapy. This study examines the relationships between plasma phospholipid levels of the n-3 fatty acids in fish oil, EPA and DHA, and remission and DMARD use in recent-onset RA. EPA and DHA were measured in blood samples… 
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The Mediterranean diet, fish oil supplements and Rheumatoid arthritis outcomes: evidence from clinical trials.
Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease.
TLDR
Effect of increased intake of fish- and plant-based omega-3 for all-cause mortality, cardiovascular (CVD) events, adiposity and lipids is assessed and it is suggested that LCn3 probably makes little or no difference to CHD event risk.
Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease.
TLDR
Meta-analysis and sensitivity analyses suggested little or no effect of increasing LCn3 on all-cause mortality, coronary heart disease (CHD) mortality, cardiovascular mortality and stroke, and it may makelittle or no difference to CHD events.
High Variability in Erythrocyte, Plasma and Whole Blood EPA and DHA Levels in Response to Supplementation
TLDR
There was high variability in response to the supplement in erythrocytes, plasma and whole blood across the different doses, which should be taken into account in clinical trials using n-3 LCPUFA supplements.
Are dietary vitamin D, omega-3 fatty acids and folate associated with treatment results in patients with early rheumatoid arthritis? Data from a Swedish population-based prospective study
TLDR
Higher intake of dietary vitamin D and omega-3 FA during the year preceding DMARD initiation may be associated with better treatment results in patients with early RA.
Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease.
BACKGROUND Omega-3 polyunsaturated fatty acids from oily fish (long-chain omega-3 (LCn3)), including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)), as well as from plants…
Effect of omega-3 fatty acids on cardiovascular outcomes: A systematic review and meta-analysis
Polyunsaturated fatty acids for the primary and secondary prevention of cardiovascular disease.
TLDR
Assessment of effects of increasing total PUFA intake on cardiovascular disease and all-cause mortality, lipids and adiposity in adults found that effects are unclear as evidence is of very low quality.
Polyunsaturated fatty acids for the primary and secondary prevention of cardiovascular disease.
TLDR
Assessment of effects of increasing total PUFA intake on cardiovascular disease and all-cause mortality, lipids and adiposity in adults with or without cardiovascular disease found that effects are unclear as evidence is of very low quality.
Rheumatoid arthritis and dietary interventions: systematic review of clinical trials.
TLDR
Some dietary approaches may improve RA symptoms and thus it is recommended that nutrition should be routinely addressed.
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References

SHOWING 1-10 OF 26 REFERENCES
Fish oil in recent onset rheumatoid arthritis: a randomised, double-blind controlled trial within algorithm-based drug use
TLDR
FO was associated with benefits additional to those achieved by combination ‘treat-to-target’ DMARDs with similar MTX use, which included reduced triple DMARD failure and a higher rate of ACR remission.
Fish oil and rheumatoid arthritis: past, present and future
TLDR
The aim is to intervene before joint damage has occurred in a current randomised controlled trial of fish oil in recent-onset RA, where the argument for its adjunctive use in RA is strong.
Validation of a meta-analysis: the effects of fish oil in rheumatoid arthritis.
Effects of fish-oil supplementation on myocardial fatty acids in humans.
TLDR
The results of the present study show that dietary n-3 fatty acids are rapidly incorporated into human myocardial phospholipids at the expense of arachidonic acid during high-dose fish-oil supplementation.
The Omega-3 Index: a new risk factor for death from coronary heart disease?
Pitfalls in the use of randomised controlled trials for fish oil studies with cardiac patients.
TLDR
It is possible that the changing pattern of fish consumption and fish oil use over time, especially in cardiac patients, can explain the disparity where benefit was observed in the early fish oil trials but not in the more recent trials.
Dietary omega-3 fats for treatment of inflammatory joint disease: efficacy and utility.
Short-term n-3 fatty acid supplementation but not aspirin increases plasma proresolving mediators of inflammation[S]
TLDR
N-3 fatty acid supplementation for 5 days results in concentrations of SPMs that are biologically active in healthy humans, and aspirin administered after n- 3 fatty acids did not offer any additional benefit in elevating the levels of S PMs.
Incorporation and clearance of omega-3 fatty acids in erythrocyte membranes and plasma phospholipids.
TLDR
Erythrocyte membrane EPA+DHA increases during relatively short intervals in response to supplementation at rates related to amount of supplementation, and may be useful to establish appropriate dosage for omega-3 fatty acid supplementation.
Response-driven combination therapy with conventional disease-modifying antirheumatic drugs can achieve high response rates in early rheumatoid arthritis with minimal glucocorticoid and nonsteroidal anti-inflammatory drug use.
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