Plasma microRNAs are sensitive indicators of inter-strain differences in the severity of liver injury induced in mice by a choline- and folate-deficient diet.

@article{Tryndyak2012PlasmaMA,
  title={Plasma microRNAs are sensitive indicators of inter-strain differences in the severity of liver injury induced in mice by a choline- and folate-deficient diet.},
  author={Volodymyr P. Tryndyak and John R. Latendresse and Beverly Montgomery and Sharon Ann Ross and Frederick A Beland and Ivan Rusyn and Igor P Pogribny},
  journal={Toxicology and applied pharmacology},
  year={2012},
  volume={262 1},
  pages={52-9}
}
MicroRNAs (miRNAs) are a class of small, conserved, tissue-specific regulatory non-coding RNAs that modulate a variety of biological processes and play a fundamental role in the pathogenesis of major human diseases, including nonalcoholic fatty liver disease (NAFLD). However, the association between inter-individual differences in susceptibility to NAFLD and altered miRNA expression is largely unknown. In view of this, the goals of the present study were (i) to determine whether or not… CONTINUE READING

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