Plasma miR-208 as a biomarker of myocardial injury.

@article{Ji2009PlasmaMA,
  title={Plasma miR-208 as a biomarker of myocardial injury.},
  author={Xu Yin Ji and Rie Takahashi and Yumiko Hiura and Go Hirokawa and Yasue Fukushima and Naoharu Iwai},
  journal={Clinical chemistry},
  year={2009},
  volume={55 11},
  pages={1944-9}
}
BACKGROUND MicroRNAs (miRNAs) are endogenous small RNAs of 21-25 nucleotides that can pair with sites in 3' untranslated regions in mRNAs of protein-coding genes to downregulate their expression. Recently, circulating miRNAs have been reported as promising biomarkers for various pathologic conditions. We assessed the hypothesis that miRNAs may leak into the circulating blood from injured cells and thereby serve as biomarkers for identifying the injured cell type. METHODS We used isoproterenol… CONTINUE READING

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