Plasma methionine depletion and pharmacokinetic properties in mice of methionine γ-lyase from Citrobacter freundii, Clostridium tetani and Clostridium sporogenes.

@article{Morozova2017PlasmaMD,
  title={Plasma methionine depletion and pharmacokinetic properties in mice of methionine γ-lyase from Citrobacter freundii, Clostridium tetani and Clostridium sporogenes.},
  author={Elena A. Morozova and Natalya V Anufrieva and Denis Zh Davydov and M. V. Komarova and Ilya N. Dyakov and Alexei N Rodionov and Tatyana V. Demidkina and V S Pokrovsky},
  journal={Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie},
  year={2017},
  volume={88},
  pages={978-984}
}
PK studies were carried out after a single i.v. administration of 500 and 1000 U/kg by measuring of MGL activity in plasma samples. L-methionine concentration was measured by mass spectrometry. After single i.v. injection of 500U/kg the circulating T1/2 of enzymes in mice varies from 73 to 123min. The AUC0-tinf values determined for MGL 500U/kg from C… CONTINUE READING