Plasma membranes as heat stress sensors: from lipid-controlled molecular switches to therapeutic applications.

@article{Trk2014PlasmaMA,
  title={Plasma membranes as heat stress sensors: from lipid-controlled molecular switches to therapeutic applications.},
  author={Zsolt T{\"o}r{\"o}k and Tim Crul and Bruno Maresca and Gerhard J Sch{\"u}tz and F{\'e}lix Viana and Laura A Dindia and Stefano Piotto and Mario Brameshuber and G{\'a}bor Balogh and M{\'a}ria P{\'e}ter and Amalia Porta and Alfonso Trapani and Imre Gombos and Attila Glatz and Burcin Gungor and Beg{\"u}m Peksel and Balint Csoboz and Ibolya Horv{\'a}th and Mathilakath M Vijayan and Phillip L Hooper and John L Harwood and Laszlo Vigh},
  journal={Biochimica et biophysica acta},
  year={2014},
  volume={1838 6},
  pages={1594-618}
}
The classic heat shock (stress) response (HSR) was originally attributed to protein denaturation. However, heat shock protein (Hsp) induction occurs in many circumstances where no protein denaturation is observed. Recently considerable evidence has been accumulated to the favor of the "Membrane Sensor Hypothesis" which predicts that the level of Hsps can be changed as a result of alterations to the plasma membrane. This is especially pertinent to mild heat shock, such as occurs in fever. In… CONTINUE READING
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