Plasma membranes as heat stress sensors: from lipid-controlled molecular switches to therapeutic applications.

  title={Plasma membranes as heat stress sensors: from lipid-controlled molecular switches to therapeutic applications.},
  author={Zsolt T{\"o}r{\"o}k and Tim Crul and Bruno Maresca and Gerhard J Sch{\"u}tz and F{\'e}lix Viana and Laura A Dindia and Stefano Piotto and Mario Brameshuber and G{\'a}bor Balogh and M{\'a}ria P{\'e}ter and Amalia Porta and Alfonso Trapani and Imre Gombos and Attila Glatz and Burcin Gungor and Beg{\"u}m Peksel and Balint Csoboz and Ibolya Horv{\'a}th and Mathilakath M Vijayan and Phillip L Hooper and John L Harwood and Laszlo Vigh},
  journal={Biochimica et biophysica acta},
  volume={1838 6},
The classic heat shock (stress) response (HSR) was originally attributed to protein denaturation. However, heat shock protein (Hsp) induction occurs in many circumstances where no protein denaturation is observed. Recently considerable evidence has been accumulated to the favor of the "Membrane Sensor Hypothesis" which predicts that the level of Hsps can be changed as a result of alterations to the plasma membrane. This is especially pertinent to mild heat shock, such as occurs in fever. In… CONTINUE READING
22 Citations
367 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 22 extracted citations


Publications referenced by this paper.
Showing 1-10 of 367 references


  • A. Y. Kim, Z. Tang, +4 authors X. Dong
  • a phosphoinositide-binding protein, functions as…
  • 2008
Highly Influential
20 Excerpts

Adaptation of membrane fluidity of rye and wheat seedlings according to temperature

  • L. Vigh, I. Horvath, T. Farkas, L. I. Horvath, A. Belea
  • Phytochemistry 18
  • 1979
Highly Influential
19 Excerpts


  • R. L. Daniels
  • Takashima, D.D. McKemy, Activity of the neuronal…
  • 2009
Highly Influential
20 Excerpts

Vigh,Membrane-associated stress proteins: more than simply chaperones, Biochim

  • I.Horvath, G.Multhoff, L. A. Sonnleitner
  • Biophys. Acta
  • 2008
Highly Influential
4 Excerpts

Similar Papers

Loading similar papers…