Plasma membrane tension orchestrates membrane trafficking, cytoskeletal remodeling, and biochemical signaling during phagocytosis.

@article{Masters2013PlasmaMT,
  title={Plasma membrane tension orchestrates membrane trafficking, cytoskeletal remodeling, and biochemical signaling during phagocytosis.},
  author={Thomas A. Masters and Bruno Pontes and Virgile Viasnoff and Yuzhen Li and Nils C Gauthier},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 29},
  pages={
          11875-80
        }
}
Phagocytes clear the body of undesirable particles such as infectious agents and debris. To extend pseudopods over the surface of targeted particles during engulfment, cells must change shape through extensive membrane and cytoskeleton remodeling. We observed that pseudopod extension occurred in two phases. In the first phase, pseudopods extended rapidly, with actin polymerization pushing the plasma membrane forward. The second phase occurred once the membrane area from preexisting reservoirs… CONTINUE READING
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