Plasma membrane nucleolin is a receptor for the anticancer aptamer AS1411 in MV4-11 leukemia cells.

Abstract

AS1411 is a DNA aptamer that is in phase II clinical trials for relapsed or refractory acute myeloid leukemia and for renal cell carcinoma. AS1411 binds to nucleolin, a protein that is overexpressed in the cytoplasm and on the plasma membrane of some tumor cells compared with normal cells. Studies were performed to determine whether cell surface nucleolin… (More)
DOI: 10.1124/mol.109.055947

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@article{Soundararajan2009PlasmaMN, title={Plasma membrane nucleolin is a receptor for the anticancer aptamer AS1411 in MV4-11 leukemia cells.}, author={Sridharan Soundararajan and Li Wang and Vijayalakshmi Sridharan and Weiwei Chen and Nigel S. Courtenay-Luck and David Jones and Eleanor K. Spicer and Daniel J Fernandes}, journal={Molecular pharmacology}, year={2009}, volume={76 5}, pages={984-91} }