Plasma membrane expansion: a neuron's Herculean task

@article{Pfenninger2009PlasmaME,
  title={Plasma membrane expansion: a neuron's Herculean task},
  author={Karl H. Pfenninger},
  journal={Nature Reviews Neuroscience},
  year={2009},
  volume={10},
  pages={251-261}
}
The formation of axons and dendrites and maintenance of the neuron's vastly expanded surface require the continuous addition of new membrane. This is achieved by membrane synthesis through the secretory pathway followed by regulated vesicle fusion with the plasma membrane, typically in the distal neurite. However, it is far from simple: multiple distinct membrane carriers are used to target specific membrane domains, dendrites seem to operate semi-autonomously from the rest of the neuron, and… CONTINUE READING
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