Plasma membrane depolarization and Na,K-ATPase impairment induced by mitochondrial toxins augment leukemia cell apoptosis via a novel mitochondrial amplification mechanism.

@article{Yin2009PlasmaMD,
  title={Plasma membrane depolarization and Na,K-ATPase impairment induced by mitochondrial toxins augment leukemia cell apoptosis via a novel mitochondrial amplification mechanism.},
  author={Wu Yin and Xiang Li and Su Ying Feng and Wei Cheng and Bo Tang and Yi-Lin Shi and Zichun Hua},
  journal={Biochemical pharmacology},
  year={2009},
  volume={78 2},
  pages={191-202}
}
Na,K-ATPase is a ubiquitous transmembrane protein that regulates and maintains the intracellular Na(+) and K(+) gradient necessary for cell homeostasis. Recently, the importance of this pump in external stimuli-induced leukemia cell apoptosis has been increasingly appreciated, however, the exact role of Na,K-ATPase in mitochondrial apoptotic pathway still remains little understood. In this study, we found mitochondrial toxin rotenone caused a rapid mitochondrial membrane potential (MMP… CONTINUE READING
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