Plasma membrane compartmentalization in yeast by messenger RNA transport and a septin diffusion barrier.

@article{Takizawa2000PlasmaMC,
  title={Plasma membrane compartmentalization in yeast by messenger RNA transport and a septin diffusion barrier.},
  author={Peter A. Takizawa and Joseph L. DeRisi and James E. Wilhelm and Ronald D Vale},
  journal={Science},
  year={2000},
  volume={290 5490},
  pages={
          341-4
        }
}
Asymmetric localization of proteins plays a key role in many cellular processes, including cell polarity and cell fate determination. Using DNA microarray analysis, we identified a plasma membrane protein-encoding mRNA (IST2) that is transported to the bud tip by an actomyosin-based process. mRNA localization created a higher concentration of IST2 protein in the bud compared with that of the mother cell, and this asymmetry was maintained by a septin-mediated membrane diffusion barrier at the… CONTINUE READING

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