Plasma membrane channels formed by connexins: their regulation and functions.

  title={Plasma membrane channels formed by connexins: their regulation and functions.},
  author={Juan C. S{\'a}ez and Viviana M. Berthoud and Mar{\'i}a C. Bra{\~n}es and Agust{\'i}n D. Mart{\'i}nez and Eric C. Beyer},
  journal={Physiological reviews},
  volume={83 4},
Members of the connexin gene family are integral membrane proteins that form hexamers called connexons. Most cells express two or more connexins. Open connexons found at the nonjunctional plasma membrane connect the cell interior with the extracellular milieu. They have been implicated in physiological functions including paracrine intercellular signaling and in induction of cell death under pathological conditions. Gap junction channels are formed by docking of two connexons and are found at… 

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