Plasma membrane calcium pump (PMCA4)-neuronal nitric-oxide synthase complex regulates cardiac contractility through modulation of a compartmentalized cyclic nucleotide microdomain.

@article{Mohamed2011PlasmaMC,
  title={Plasma membrane calcium pump (PMCA4)-neuronal nitric-oxide synthase complex regulates cardiac contractility through modulation of a compartmentalized cyclic nucleotide microdomain.},
  author={Tamer M A Mohamed and Delvac Oceandy and Min Zi and Sukhpal Prehar and Nasser Alatwi and Yanwen Wang and Mohamed A. Shaheen and Riham Abou-Leisa and Celine Schelcher and Zeinab Hegab and Florence Baudoin and Michael N Emerson and Mamas Mamas and Giulietta Di Benedetto and Manuela Zaccolo and Ming Lei and Elizabeth J. Cartwright and Ludwig Neyses},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 48},
  pages={41520-9}
}
Identification of the signaling pathways that regulate cyclic nucleotide microdomains is essential to our understanding of cardiac physiology and pathophysiology. Although there is growing evidence that the plasma membrane Ca(2+)/calmodulin-dependent ATPase 4 (PMCA4) is a regulator of neuronal nitric-oxide synthase, the physiological consequence of this… CONTINUE READING