Plasma membrane calcium ATPases as novel candidates for therapeutic agent development.

@article{Strehler2013PlasmaMC,
  title={Plasma membrane calcium ATPases as novel candidates for therapeutic agent development.},
  author={Emanuel E. Strehler},
  journal={Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques},
  year={2013},
  volume={16 2},
  pages={190-206}
}
Plasma membrane Ca2+ ATPases (PMCAs) are highly regulated transporters responsible for Ca2+ extrusion from all eukaryotic cells. Different PMCA isoforms are implicated in various tasks of Ca2+ regulation including bulk Ca2+ transport and localized Ca2+ signaling in specific membrane microdomains. Accumulating evidence shows that loss, mutation or inappropriate expression of different PMCAs is associated with pathologies ranging from hypertension, low bone density and male infertility to hearing… CONTINUE READING