Plasma membrane GPIIb/IIIa. Evidence for a cycling receptor pool.

  title={Plasma membrane GPIIb/IIIa. Evidence for a cycling receptor pool.},
  author={J D Wencel-Drake},
  journal={The American journal of pathology},
  volume={136 1},
The author used immunofluorescence and digital image processing to investigate the dynamic distribution of GPIIb/IIIa in living platelets. Resting cells were incubated with AP-2, a complex-specific, monoclonal, anti-GPIIb/IIIa antibody. Examination of intact cells demonstrated a rim pattern for GPIIb/IIIa consistent with a surface localization. Permeabilization revealed a time-dependent increase in the labeling of apparent intracellular vacuoles. This pattern is distinct from the "patch-cap… CONTINUE READING

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