Plasma membrane Ca2+ ATPase 4 is required for sperm motility and male fertility.

@article{Schuh2004PlasmaMC,
  title={Plasma membrane Ca2+ ATPase 4 is required for sperm motility and male fertility.},
  author={K Schuh and Elizabeth J. Cartwright and Eriks Jankevics and Karin Bundschu and Juergen Liebermann and Judith C. Williams and Angel Luis Armesilla and Michael Emerson and Delvac Oceandy and Klaus-Peter Knobeloch and Ludwig Neyses},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 27},
  pages={28220-6}
}
Calcium and Ca(2+)-dependent signals play a crucial role in sperm motility and mammalian fertilization, but the molecules and mechanisms underlying these Ca(2+)-dependent pathways are incompletely understood. Here we show that homozygous male mice with a targeted gene deletion of isoform 4 of the plasma membrane calcium/calmodulin-dependent calcium ATPase (PMCA), which is highly enriched in the sperm tail, are infertile due to severely impaired sperm motility. Furthermore, the PMCA inhibitor 5… CONTINUE READING

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