Plasma matrix metalloproteinase 1 improves the detection and survival prediction of esophageal squamous cell carcinoma

@article{Chen2016PlasmaMM,
  title={Plasma matrix metalloproteinase 1 improves the detection and survival prediction of esophageal squamous cell carcinoma},
  author={Yu‐Kuei Chen and Chun-Wei Tung and Jui-Ying Lee and Yi-Chun Hung and Chien-Hung Lee and Shah Hwa Chou and Hung-Shun Lin and Ming-Tsang Wu and I-Chen Wu},
  journal={Scientific Reports},
  year={2016},
  volume={6}
}
This study aimed to identify noninvasive protein markers capable of detecting the presence and prognosis of esophageal squamous-cell carcinoma (ESCC). Analyzing microarray expression data collected from 17-pair ESCC specimens, we identified one protein, matrix metalloproteinase-1 (MMP1), as a possibly useful marker. Plasma MMP1 was then measured by enzyme-linked immunosorbent assay (ELISA) in 210 ESCC patients and 197 healthy controls. ESCC patients had higher mean levels of MMP1 than controls… 
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