Plasma lipoproteins in familial dysbetalipoproteinemia associated with apolipoproteins E2(Arg158-->Cys), E3-Leiden, and E2(Lys146-->Gln), and effects of treatment with simvastatin.

@article{Zhao1994PlasmaLI,
  title={Plasma lipoproteins in familial dysbetalipoproteinemia associated with apolipoproteins E2(Arg158-->Cys), E3-Leiden, and E2(Lys146-->Gln), and effects of treatment with simvastatin.},
  author={Su Ping Zhao and August H M Smelt and Arn M. J. M. van den Maagdenberg and Arie van Tol and Ton F. F. P. Vroom and Jan A Gevers Leuven and Rune R. Frants and Louis M. Havekes and Arnoud van der Laarse and F M van 't Hooft},
  journal={Arteriosclerosis and thrombosis : a journal of vascular biology},
  year={1994},
  volume={14 11},
  pages={1705-16}
}
Using a density-gradient ultracentrifugation technique, we analyzed in detail the plasma lipoprotein profiles of 18 patients with familial dysbetalipoproteinemia (FD) who had apolipoprotein (apo) E2(Arg158-->Cys) homozygosity (the E2-158 variant, n = 6), apoE3-Leiden heterozygosity (the E3-Leiden variant, n = 6), or apoE2(Lys146-->Gln) heterozygosity (the E2-146 variant, n = 6), with average plasma cholesterol concentrations of 8.99 +/- 1.34 mmol/L, 9.29 +/- 1.55 mmol/L, and 8.46 +/- 1.10 mmol… CONTINUE READING