Plasma levels of soluble CD105 correlate with metastasis in patients with breast cancer.

@article{Li2000PlasmaLO,
  title={Plasma levels of soluble CD105 correlate with metastasis in patients with breast cancer.},
  author={Chenggang Li and Botao Guo and Paul Wilson and Alan L. Stewart and Ged J. Byrne and Nigel J. Bundred and Shant Kumar},
  journal={International journal of cancer},
  year={2000},
  volume={89 2},
  pages={122-6}
}
CD105 (endoglin), a receptor for transforming growth factor (TGF) beta1 and beta3 in vascular endothelial cells, is highly up-regulated in blood vessels of tissues where neovascularisation occurs. It modulates endothelial-mesenchymal signalling and is essential for angiogenesis. Indeed, CD105 knock-out mice die from malvascularisation by 11.5 day p.c. In the present study CD105, TGFbeta1 and CD105/TGFbeta1 complexes were quantified in plasma samples from 77 healthy individuals and 92 patients… CONTINUE READING

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