Plasma levels of receptor activator of nuclear factor-kappaB ligand and osteoprotegerin in patients with neuroblastoma.

@article{Granchi2006PlasmaLO,
  title={Plasma levels of receptor activator of nuclear factor-kappaB ligand and osteoprotegerin in patients with neuroblastoma.},
  author={Donatella Granchi and Alberto Garaventa and Ilaria Amato and Paolo Paolucci and Nicola Baldini},
  journal={International journal of cancer},
  year={2006},
  volume={119 1},
  pages={146-51}
}
Earlier reports showed that the balance between receptor activator of nuclear factor-kappaB ligand (RANKL) and its decoy-receptor osteoprotegerin (OPG) plays an important role in the pathogenesis of metastatic osteolysis induced by neuroblastoma cells. In this study, we investigated whether circulating levels of OPG, RANKL and their ratio were associated to the presence of osteolytic lesions in advanced neuroblastoma, as well as whether they provided additional information on the severity and… CONTINUE READING

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