Plasma levels of matrix metalloproteinase-9: a possible diagnostic marker of successful endovascular aneurysm repair.

Abstract

OBJECTIVE The aim of the study was evaluating the diagnostic value of plasma matrix metalloproteinase- (MMP)-2 and -9 and tissue inhibitor of MMP-1 (TIMP-1) for endoleak detection after endovascular aneurysm repair (EVAR). REPORT Consecutive EVAR patients (n = 17) with endoleak and matched controls without endoleak (n = 20) were prospectively enrolled. Increased levels of MMP-9 were observed in patients with endoleak (P < 0.001). Regression analysis showed no significant influence of age, sex or abdominal aortic aneurysm (AAA) size. The receiver operating characteristic (ROC) curve of plasma MMP-9 levels showed that a cut-off value of 55.18 ng ml(-1) resulted in 100% sensitivity and 96% specificity with an AUC value of 0.988 (P < 0.001) to detect endoleak. CONCLUSIONS Plasma MMP-9 levels appear to discriminate between patients with and without an endoleak with high sensitivity and specificity.

DOI: 10.1016/j.ejvs.2011.10.014

Cite this paper

@article{Hellenthal2012PlasmaLO, title={Plasma levels of matrix metalloproteinase-9: a possible diagnostic marker of successful endovascular aneurysm repair.}, author={Femke A. M. V. I. Hellenthal and Jan A ten Bosch and Bianca Pulinx and Will K. W. H. Wodzig and Michiel Willem de Haan and Martin Prins and R. J. T. J. Welten and Joep A. W. Teijink and Geert Willem H. Schurink}, journal={European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery}, year={2012}, volume={43 2}, pages={171-2} }