Plasma levels of TNF-alpha and IL-6 are inversely related to cytochrome P450-dependent drug metabolism in patients with congestive heart failure.

@article{Frye2002PlasmaLO,
  title={Plasma levels of TNF-alpha and IL-6 are inversely related to cytochrome P450-dependent drug metabolism in patients with congestive heart failure.},
  author={R F Frye and Virginia M Schneider and Carole S. Frye and Arthur M Feldman},
  journal={Journal of cardiac failure},
  year={2002},
  volume={8 5},
  pages={
          315-9
        }
}
BACKGROUND Cytochrome P450 (CYP) enzymes are important mediators of drug metabolism, and activity of these enzymes is a major determinant of the duration and intensity of drug effect. Circulating plasma concentrations of pro-inflammatory cytokines (e.g., tumor necrosis factor [TNF]-alpha and interleukin [IL]-6) are elevated in patients with heart failure and these cytokines have been shown to down-regulate CYP enzyme activity. The purpose of this study was to evaluate the relationship between… CONTINUE READING
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