Inflammation-induced phenoconversion of polymorphic drug metabolizing enzymes: hypothesis with implications for personalized medicine.
- Rashmi R Shah, Robert L. Smith
- Drug metabolism and disposition: the biological…
- 2015
Highly Influenced
6 Excerpts
Plasma levels of TNF-alpha and IL-6 are inversely related to cytochrome P450-dependent drug metabolism in patients with congestive heart failure.
@article{Frye2002PlasmaLO,
title={Plasma levels of TNF-alpha and IL-6 are inversely related to cytochrome P450-dependent drug metabolism in patients with congestive heart failure.},
author={R F Frye and Virginia M Schneider and Carole S. Frye and Arthur M Feldman},
journal={Journal of cardiac failure},
year={2002},
volume={8 5},
pages={
315-9
}
}- Published in Journal of cardiac failure 2002
BACKGROUND
Cytochrome P450 (CYP) enzymes are important mediators of drug metabolism, and activity of these enzymes is a major determinant of the duration and intensity of drug effect. Circulating plasma concentrations of pro-inflammatory cytokines (e.g., tumor necrosis factor [TNF]-alpha and interleukin [IL]-6) are elevated in patients with heart failure and these cytokines have been shown to down-regulate CYP enzyme activity. The purpose of this study was to evaluate the relationship between… CONTINUE READING