Plasma levels of MASP-1, MASP-3 and MAp44 in patients with type 2 diabetes: influence of glycaemic control, body composition and polymorphisms in the MASP1 gene.

@article{Krogh2017PlasmaLO,
  title={Plasma levels of MASP-1, MASP-3 and MAp44 in patients with type 2 diabetes: influence of glycaemic control, body composition and polymorphisms in the MASP1 gene.},
  author={S S Krogh and Charlotte Berg Holt and Rudi M Steffensen and Kristian L\okke Funck and Pernille H\oyem and Esben Laugesen and Per L\ogstrup Poulsen and Steffen Thiel and T. K. Hansen},
  journal={Clinical and experimental immunology},
  year={2017},
  volume={189 1},
  pages={
          103-112
        }
}
Mounting evidence indicates that adverse activation of the complement system plays a role in the development of diabetic vascular complications. Plasma levels of the complement proteins mannan-binding lectin (MBL) and its associated serine proteases (MASP-1 and MASP-2) are elevated in diabetes. We hypothesized that single nucleotide polymorphisms (SNPs) in the MASP1 gene may contribute to altered plasma levels of the belonging gene products; MASP-1, MASP-3 and mannan-binding lectin-associated… CONTINUE READING