Plasma levels of F-actin and F:G-actin ratio as potential new biomarkers in patients with septic shock.

Abstract

OBJECTIVE To compare plasma levels of F-actin, G-actin and thymosin beta 4 (TB4) in humans with septic shock, noninfectious systemic inflammatory response syndrome (SIRS) and healthy controls. RESULTS F-actin was significantly elevated in septic shock as compared with noninfectious SIRS and healthy controls. G-actin levels were greatest in the noninfectious SIRS group but significantly elevated in septic shock as compared with healthy controls. TB4 was not detectable in the septic shock or noninfectious SIRS group above the assay's lowest detection range (78 ng/ml). CONCLUSIONS F-actin is significantly elevated in patients with septic shock as compared with noninfectious SIRS. F-actin and the F:G-actin ratio are potential biomarkers for the diagnosis of septic shock.

DOI: 10.3109/1354750X.2015.1126646

Cite this paper

@article{Belsky2016PlasmaLO, title={Plasma levels of F-actin and F:G-actin ratio as potential new biomarkers in patients with septic shock.}, author={Justin Brett Belsky and Daniel C Morris and Ralph Bouchebl and Michael R. Filbin and Kevin R. Bobbitt and Anja Kathrina Jaehne and Emanuel Phillip Rivers}, journal={Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals}, year={2016}, volume={21 2}, pages={180-5} }