Plasma levels and urinary excretion of methyl-GAG following iv infusion in man.

@article{Marsh1981PlasmaLA,
  title={Plasma levels and urinary excretion of methyl-GAG following iv infusion in man.},
  author={Kennan C. Marsh and J Liesmann and Thomas F. Patton and Carol J. Fabian and L. A. Sternson},
  journal={Cancer treatment reports},
  year={1981},
  volume={65 3-4},
  pages={253-7}
}
The pharmacokinetics of methyl-GAG was studied after nephrectomy in five patients with renal cell carcinoma and in one patient with breast cancer. Following rapid infusion (30 minutes) of 700 mg/m2 of methyl-GAG, terminal half-life of 136-224 hours. Drug levels declined to 6%-20% of the initial plasma concentration in the first 24 hours. Approximately 40% of the dose was recovered in the urine after 2 weeks. Extensive extravascular distribution of methyl-GAG is suggested.