Plasma levels and symptom complaints in patients maintained on daily dosage of methadone hydrochloride.

@article{Horns1975PlasmaLA,
  title={Plasma levels and symptom complaints in patients maintained on daily dosage of methadone hydrochloride.},
  author={W H Horns and Marta Rado and Avram Goldstein},
  journal={Clinical pharmacology and therapeutics},
  year={1975},
  volume={17 6},
  pages={
          636-49
        }
}
Plasma methadone levels, symptom complaints, and urine tests for illicit opiate use were followed weekly in 17 patients on a methadone maintenance program. There were very large differences between patients in the plasma level established at a given dosage, implying large differences in the rate of methadone metabolism. Despite virtually constant daily dosage, the plasma methadone levels fluctuated greatly from week to week and from day to day in individual patients. With rate exceptions there… CONTINUE READING

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