Plasma levels and effect on heart rate and blood pressure of metoprolol after acute oral administration in 12 geriatric patients.

@article{Lundborg1976PlasmaLA,
  title={Plasma levels and effect on heart rate and blood pressure of metoprolol after acute oral administration in 12 geriatric patients.},
  author={P. Lundborg and Bertil Steen},
  journal={Acta medica Scandinavica},
  year={1976},
  volume={200 5},
  pages={397-402}
}
Metoprolol, a cardioselective beta-blocking agent, has been given orally to 12 geriatric patients with moderate hypertension. Drug levels of metoprolol as well as the effect of the drug on resting heart rate and BP were studied. Metoprolol was given in a dose of 20 mg, and 8 of the 12 patients also received a 50 mg dose. After the 20 mg dose the peak drug plasma concentration varied between 5 and 80 ng/ml (mean 33), and after the 50 mg dose between 14 and 212 ng/ml (mean 111). This variation is… CONTINUE READING

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