Plasma level of cardiotrophin-1 as a prognostic predictor in patients with chronic heart failure.

Abstract

BACKGROUND Cardiotrophin-1 (CT-1) is a member of the interleukin (IL-6) family of cytokines and is increased in patients with chronic heart failure (CHF). AIMS To evaluate the prognostic role of CT-1 in patients with CHF. METHODS AND RESULTS We measured the plasma levels of CT-1, brain natriuretic peptide (BNP), and IL-6 in 125 patients with CHF. Patients were monitored for a mean follow-up period of 2.9 years. Plasma levels of CT-1 increased with severity of CHF. There was a significant negative correlation between plasma CT-1 and left ventricular ejection fraction. There was a significant correlation between plasma CT-1 and log IL-6. During the follow-up period, 37 patients died. High plasma levels of CT-1, BNP, and IL-6 were independent predictors of mortality on stepwise multivariate analysis. The hazard ratio for mortality in patients with plasma BNP>170 pg/mL and CT-1>658 fmol/mL was 2.48 (95% confidence interval, 1.217-5.060) compared to those with plasma BNP>170 pg/mL and CT-1<658 fmol/mL (p=0.0124). CONCLUSION These findings indicate that plasma CT-1 measurement provides additional prognostic information and that combined levels of CT-1 and BNP are more accurate at predicting mortality in patients with CHF than either marker alone.

Cite this paper

@article{Tsutamoto2007PlasmaLO, title={Plasma level of cardiotrophin-1 as a prognostic predictor in patients with chronic heart failure.}, author={Takayoshi Tsutamoto and Shigeru Asai and Toshinari Tanaka and Hiroshi Sakai and Keizo Nishiyama and Masanori Fujii and Takashi Yamamoto and Masato Ohnishi and Atsuyuki Wada and Yoshihiko Saito and Minoru Horie}, journal={European journal of heart failure}, year={2007}, volume={9 10}, pages={1032-7} }