Plasma leptin is partly cleared by the kidney and is elevated in hemodialysis patients.

@article{Sharma1997PlasmaLI,
  title={Plasma leptin is partly cleared by the kidney and is elevated in hemodialysis patients.},
  author={Kumar Sharma and Robert Vincent Considine and Beckie Michael and Stephen R. Dunn and Lawrence S. Weisberg and Blaz Kurnik and Peter B Kurnik and John O'Connor and Madhur K. Sinha and J. Fern{\'a}ndez Caro},
  journal={Kidney international},
  year={1997},
  volume={51 6},
  pages={1980-5}
}
Leptin, the gene product of the ob gene, is important in the control of appetite in rodents and may have an important role in humans. The clearance of leptin from the circulation is unknown. As the leptin receptor is present in the kidney, we evaluated the role of the kidney in removing circulating leptin in humans. We measured leptin in aortic and renal vein plasma in 8 patients with intact renal function and 6 patients with impaired renal function who were undergoing elective cardiac… CONTINUE READING
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