Plasma leptin concentrations do not appear to decrease insulin-mediated glucose disposal or glucose-stimulated insulin secretion in women with normal glucose tolerance.

@article{Carantoni1998PlasmaLC,
  title={Plasma leptin concentrations do not appear to decrease insulin-mediated glucose disposal or glucose-stimulated insulin secretion in women with normal glucose tolerance.},
  author={M Carantoni and Fahim A. Abbasi and Salman Azhar and Y D Chen and Matvei Klebanov and Pei-wen Wang and F A R M Warmerdam and Gerald Mark Reaven},
  journal={Diabetes},
  year={1998},
  volume={47 2},
  pages={244-7}
}
The aim of this study was to test the hypothesis that plasma leptin concentrations contributed to the pathophysiology of NIDDM by decreasing both insulin-mediated glucose disposal and glucose-stimulated insulin secretion. The study was performed in 60 women with normal oral glucose tolerance. Differences in insulin-mediated glucose disposal were determined by comparing the steady-state plasma glucose (SSPG) concentrations attained at the end of a 180-min constant infusion of somatostatin… CONTINUE READING

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