Corpus ID: 34062968

Plasma kinetics of diphenylhydantoin in dogs and cats.

  title={Plasma kinetics of diphenylhydantoin in dogs and cats.},
  author={D. B. Roye and E. E. Serrano and R. Hammer and B. Wilder},
  journal={American journal of veterinary research},
  volume={34 7},
Duration of vaccine-induced immunity
Changes in vaccination schedules, particularly the prolongation of the booster intervals for some vaccine components, represents a challenge for veterinarians as well as for pet owners. For manyExpand
Systematic review of antiepileptic drugs’ safety and effectiveness in feline epilepsy
An evidence-based assessment of the published data on the AEDs’ efficacy and safety for feline epilepsy showed that phenobarbital might currently be considered as the first choice AED followed by levetiracetam and imepitoin, and only imePitoin’s safety profile was supported by strong level of evidence. Expand
The effects of phenytoin dosage on the induction of α1-acid glycoprotein and antipyrine clearance in the dog
  • F. Abramson, M. Lutz
  • Chemistry, Medicine
  • European Journal of Drug Metabolism and Pharmacokinetics
  • 2010
Doses of phenytoin from 90 to 800 mg/d were used to study induction of hepatic cytochrome P-450 and plasma α1-racid glycoprotein in dogs, suggesting a complex mechanism of induction. Expand
Characterization of cytochrome P450-mediated drug metabolism in cats.
Although there is no sexual difference in CYP1A activities, there are differences in CyP2D and 3A activities of cats, suggesting that CYP2C substrates should be carefully administered to cats. Expand
Fosphenytoin and Phenytoin in Patients with Status Epilepticus
Fosphenytoin, a phenytoin prodrug, has the same pharmacological properties as phenyToin but none of the injection site and cardiac rhythm complications of intravenous infusions of pheny toin, and costs more than intravenous pheny Toin, treating the acute and chronic complications of TCSE itself, and the complications of infusion can also be costly. Expand
Phenytoin covalent binding and embryopathy in mouse embryos co-cultured with maternal hepatocytes from mouse, rat, and rabbit.
The results suggest that mouse embryos intrinsically can bioactivate phenytoin to a toxic reactive intermediate, with embryopathic consequences, and that maternal determinants may contribute variably to teratologic susceptibility in a species-specific manner. Expand
Management of toxicoses.
  • V. Beasley, D. Dorman
  • Medicine
  • The Veterinary clinics of North America. Small animal practice
  • 1990
Information is provided on the detoxification of and supportive care for poisoned animals that is often of paramount importance in an effort to limit organ damage and to enable a poisoned animal to survive. Expand
Medical management of recurrent seizures in dogs and cats.
This study will review the available literature regarding the pharmacology, use, and side effects of anticonvulsant drugs currently available for control of recurrent seizures in companion animals. Expand
Pharmacokinetics of three formulations of diphenylhydantoin in the dog.
The pharmacokinetics of the sodium salt of diphenylhydantoin was studied in three healthy dogs, using three formulations, a capsule, a tablet and a suspension. The results were essentially the sameExpand
Pharmacokinetics of anti-epileptic drugs in the dog: a review.
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