Plasma insulin, IGF-binding proteins-1 and -2 and risk of colorectal cancer: a prospective study in northern Sweden.

@article{Palmqvist2003PlasmaII,
  title={Plasma insulin, IGF-binding proteins-1 and -2 and risk of colorectal cancer: a prospective study in northern Sweden.},
  author={Richard Palmqvist and P{\"a}r Stattin and Sabina Rinaldi and Carine Biessy and Roger Stenling and Elio Riboli and G{\"o}ran Hallmans and Rudolf Kaaks},
  journal={International journal of cancer},
  year={2003},
  volume={107 1},
  pages={89-93}
}
Chronically elevated plasma insulin levels have been postulated to increase colon cancer risk, either directly through colonic insulin receptors or indirectly through downregulation of IGFBP-1 and/or IGFBP-2, thus increasing IGF activity. Our aim was to examine the relationships of plasma insulin and IGFBPs-1 and -2 with risks of colon and rectal cancers. We conducted a case-control study nested within the prospective Northern Sweden Health and Disease Cohort. Insulin and IGFBPs were measured… CONTINUE READING