Plasma imipramine levels and demethylase activity in the liver of stressed animals.

@article{Krulk1981PlasmaIL,
  title={Plasma imipramine levels and demethylase activity in the liver of stressed animals.},
  author={R. Krul{\'i}k and I Farsk{\'a} and O. Jindrov{\'a}},
  journal={Neuropsychobiology},
  year={1981},
  volume={7 1},
  pages={12-6}
}
The steady-state values in rats after a second 14-day period of daily subcutaneous administration of imipramine were the same as during the first period; liver demethylation activity rose for up to 3 days and then returned to normal. The imipramine-binding capacity of the serum, brain myelin, synaptosomes and mitochondria did not alter after repeated administration, but a decrease was found in the red blood cells. Stress (an electric current or immobilization) led to marked reduction of the… CONTINUE READING

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