Plasma homocysteine is decreased in the hypothyroid rat.

  title={Plasma homocysteine is decreased in the hypothyroid rat.},
  author={Ren{\'e} L Jacobs and Lori M Stead and Margaret E. Brosnan and John T. Brosnan},
  journal={Canadian journal of physiology and pharmacology},
  volume={78 7},
Recent clinical studies have indicated that plasma homocysteine was significantly increased in hypothyroid patients. Since hyperhomocysteinemia is an independent risk factor for cardiovascular disease we investigated homocysteine metabolism in hypothyroid rats. Hypothyroidism was induced in one study by addition of propylthiouracil (PTU) to the drinking water for 2 weeks. In a second study, thyroidectomized and sham-operated rats were used with thyroid hormone replacement via mini-osmotic pumps… CONTINUE READING